MEK1/2 Regulates Microtubule Organization, Spindle Pole Tethering and Asymmetric Division During Mouse Oocyte Meiotic Maturation
نویسندگان
چکیده
منابع مشابه
PAK1 regulates spindle microtubule organization during oocyte meiotic maturation.
P21-activated kinase 1 (PAK1), an effector of Rho GTPase Rac 1 and Cdc42, is required for mitotic progression. However, its functions in meiosis are unclear. In the present study, we examined the expression, localization and function of PAK1 during mouse oocyte meiotic maturation and found that PAK1 was mainly associated with the meiotic spindle microtubules. Taxol treatment resulted in localiz...
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Phospholipase D2 (PLD2) is involved in cytoskeletal reorganization, cell migration, cell cycle progression, transcriptional control and vesicle trafficking. There is no evidence about PLD2 function in oocytes during meiosis. Herein, we analyzed PLD2 expression and its relationship with spindle formation and positioning in mouse oocyte meiosis. High protein level of PLD2 was revealed in oocytes ...
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Stag3, a meiosis-specific subunit of cohesin complex, has been demonstrated to function in both male and female reproductive systems in mammals. However, its roles during oocyte meiotic maturation have not been fully defined. In the present study, we report that Stag3 uniquely accumulates on the spindle apparatus and colocalizes with microtubule fibers during mouse oocyte meiotic maturation. De...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2007
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.6.3.3805